The multifaceted functions and dynamics of the mitochondrial outer membrane (MOM)

Importance of the mitochondrial outer membrane (MOM)

The mitochondrial outer membrane (MOM) mediates numerous interactions between mitochondria and the rest of the cell. It plays a central role in: mitophagy, apoptosis, motility and morphology of the organelle, transfer of proteins and lipids to and from other compartments, immune response, and exchange of metabolites with the cytosol. Despite its obvious importance, the MOM is currently understudied, making our initiative highly relevant and unique. All the included projects are tightly interconnected and deal with various aspects of the same biological question: How are mitochondrial diversity, dynamics and functions coordinated and regulated at the level of the MOM?

Our goal

We intend to achieve comprehensive understanding of the structure, function, regulation, and biogenesis of the MOM.

Interdisciplinary approach

On the one end of the spectrum, we will use yeast cells to study basic mitochondrial mechanisms, and on the other, we will utilize induced pluripotent stem cells and mouse models to investigate MOM-related pathomechanisms of human diseases. Our RTG will bring together different disciplines such as protein analytics, structural biology, biophysics, cell biology, and modern imaging.

Training concept

All fellows participating in this RTG will benefit from an intense program of training measures. Our aim is to provide a cohort of young researchers the appropriate multidisciplinary background and knowhow in mitochondrial biology and to train them in techniques needed to study it. In addition, we will include in our RTG a wide spectrum of career promoting, non-scientific activities.