Publications

Generation of R272Q, S156A and K572R RHOT1/Miro1 Point Mutations in iPSCs from a Healthy Individual using FACS-assisted CRISPR/Cas9 Genome Editing

L. Schwarz, N. Casadei, J.C. Fitzgerald. Stem Cell Research (2021), doi: https://doi.org/10.1016/j.scr.2021.102469

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Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors.

Bus C, Zizmare L, Feldkaemper M, Geisler S, Zarani M, Schaedler A, Klose F, Admard J, Mageean CJ, Arena G,
Fallier-Becker P, Ugun-Klusek A, Maruszczak KK, Kapolou K, Schmid B, Rapaport D, Ueffing M, Casadei N, Krüger R,
Gasser T, Vogt Weisenhorn DM, Kahle PJ, Trautwein C, Gloeckner CJ, Fitzgerald JC.

iScience. 2020 Nov 13;23(12):101797. doi: 10.1016/j.isci.2020.101797. eCollection 2020 Dec 18. PMID: 33299968 Free PMC article.

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A novel epitope tagging system to visualize and monitor antigens in live cells with chromobodies

Bjoern Traenkle, Sören Segan, Funmilayo O Fagbadebo, Philipp D Kaiser, Ulrich Rothbauer

Sci Rep. 2020 Aug 31;10(1):14267. doi: 10.1038/s41598-020-71091-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459311/

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Drp1 modulates mitochondrial stress responses to mitotic arrest

Aida Peña-Blanco, Manuel D Haschka, Andreas Jenner, Theresia Zuleger, Tassula Proikas-Cezanne, Andreas Villunger, Ana J García-Sáez

2020, Cell Death Differ. doi: 10.1038/s41418-020-0527-y. Online ahead of print.

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The mitochondrial intermembrane space-facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism

Fenja Odendall, Sandra Backes, Takashi Tatsuta, Uri Weill, Maya Schuldiner, Thomas Langer, Johannes M Herrmann, Doron Rapaport, Kai Stefan Dimmer

2019, Mol Biol Cell. 2019 Oct 1;30(21):2681-2694.

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Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease.

Grossmann D, Berenguer-Escuder C, Bellet ME, Scheibner D, Bohler J, Massart F, Rapaport D, Skupin A, Fouquier d'Hérouël A, Sharma M, Ghelfi J, Raković A, Lichtner P, Antony P, Glaab E, May P, Dimmer KS, Fitzgerald JC, Grünewald A, Krüger R,.

Antioxid Redox Signal. 2019 Aug 21. doi: 10.1089/ars.2018.7718.

 
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  1. Structural basis of head to head polyketide fusion by CorB.
  2. Kinesin rotates unidirectionally and generates torque while walking on microtubules.
  3. A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells.
  4. Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins.
  5. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis.
  6. The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein.
  7. Here, there, everywhere. mRNA localization in budding yeast.
  8. Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division.
  9. Quantitative phosphoproteome analysis of Bacillus subtilis reveals novel substrates of the kinase PrkC and phosphatase PrpC.
  10. The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.